Restoration of chloride efflux by azithromycin in airway epithelial cells of cystic fibrosis patients.

نویسندگان

  • Vinciane Saint-Criq
  • Carine Rebeyrol
  • Manon Ruffin
  • Telma Roque
  • Loïc Guillot
  • Jacky Jacquot
  • Annick Clement
  • Olivier Tabary
چکیده

Azithromycin (AZM) has shown promising anti-inflammatory properties in chronic obstructive pulmonary diseases, and clinical studies have presented an improvement in the respiratory condition of cystic fibrosis (CF) patients. The aim of this study was to investigate, in human airway cells, the mechanism by which AZM has beneficial effects in CF. We demonstrated that AZM did not have any anti-inflammatory effect on CF airway cells but restored Cl(-) efflux.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 55 4  شماره 

صفحات  -

تاریخ انتشار 2011